New evidence says that polycystic ovary syndrome (PCOS) is caused by fast brain signals leading to fast luteinizing hormone (LH) pulses. Progesterone in the menstrual cycle slows LH pulsing. That means ovulation can occur, testosterone levels can go down and regular cycles occur. However, we don't know if this treatment with cyclic progesterone in PCOS will improve women's quality of life.

Women will take the natural hormone, progesterone 14 days a month for 6 months. It is likely to cause regular flow. After one month, women will start the second medicine, that blocks testosterone. To study the effects of these new PCOS therapies, we will test morning saliva, temperature, and a small blood test the beginning and end of the study. Each night before going to bed, women will record their everyday experiences.